Invasive Candidiasis: New Insights Presaging New Therapeutic Approaches?

Invasive candidiasis: new insights presaging new therapeutic approaches?

The expanding universe of amyloid has revealed an intriguing new galaxy, invasive candidiasis, with the publication by Gilchrist et al in this issue of the Journal. Invasive infection of the gut by Candida albicans is a serious, intractable condition that occurs most commonly but not exclusively in neutropenic patients and for which there is very poorly effective treatment. Gilchrist et al now ...

Multiple Myeloma: New Insights and Therapeutic Approaches.

This review discusses the evolution of novel diagnostic and treatment strategies for multiple myeloma based upon increased understanding of basic disease pathogenesis. Although myeloma has remained an incurable illness to date, these new developments will derive treatments to improve outcome and achieve eventual cure. In Section I, Dr. Kyle reviews the results of current therapy for multiple my...

Mechanistic Insights of Coronary Vasospasm and New Therapeutic Approaches.

Adaptive immunity in atherogenesis: new insights and therapeutic approaches.

Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and a...

Metastasis – recent scientific insights and challenging new therapeutic approaches

Majority of cancer patients never die from the original disease – primary tumor – but from the metastasis that disseminate throughout the body. Although they disseminate in millions only few of them succeeded in their journey and achieve their main goal – form a distant metastatic colony which is able to thrive in an inhospitable environment of an unrelated tissue. This review will summarize in...